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T cells are essential to the immune response and without them, the body cannot fight infections or kill cancerous cells.

The mechanism of CD4 T cell depletion, although apoptosis may also be a factor.

The risk from sharing a needle during drug injection is between 0.63 and 2.4% per act, with an average of 0.8%.

The risk of acquiring HIV from a needle stick from an HIV-infected person is estimated as 0.3% (about 1 in 333) per act and the risk following mucous membrane exposure to infected blood as 0.09% (about 1 in 1000) per act.

Preventive treatment involves the mother taking antiretrovirals during pregnancy and delivery, an elective caesarean section, avoiding breastfeeding, and administering antiretroviral drugs to the newborn.

If a woman is untreated, two years of breastfeeding results in an HIV/AIDS risk in her baby of about 17%. Due to the increased risk of death without breastfeeding in many areas in the developing world, the World Health Organization recommends either: (1) the mother and baby being treated with antiretroviral medication while breastfeeding being continued (2) the provision of safe formula.

During primary infection, the level of HIV may reach several million virus particles per milliliter of blood. This weakens the immune system and allows opportunistic infections.The resulting viral DNA is then imported into the cell nucleus and integrated into the cellular DNA by a virally encoded integrase and host co-factors.and is the cause of the majority of HIV infections globally.Thus, it is recommended that HIV be considered in people presenting an unexplained fever who may have risk factors for the infection.Between 50 and 70% of people also develop persistent generalized lymphadenopathy, characterized by unexplained, non-painful enlargement of more than one group of lymph nodes (other than in the groin) for over three to six months.

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