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In this abstract we compare the incidence of VTE in Ph ALL pts pre and post 2008 and Ph-ALL patients.Methods: We conducted a retrospective chart review of 130 adult pts with Ph ALL treated at Princess Margaret Cancer Center between 2001-2015.We love them and specialize in keeping these beauties on the road and in the hands of proud owners like Jas D.He picked up this 1990 300zx Twin Turbo last summer and visited Z Car Garage for a thorough inspection.Discussion: We have previously identified an incidence of 21.7% VTE in Ph - ALL patients treated with a modified DFCI chemotherapy that occurred during intensification.The current series describes a similar rate (19.2%) of VTE in Ph ALL patients despite over 2/3 of these patients never receiving ASNase.It has been suggested that the incidence of VTE in ALL pts is affected by the use of L-Asparaginase (ASNase) which is an integral part of many chemotherapy regimens.Consistent with this we previously reported a high VTE rate (22%) in pts with Philadelphia chromosome negative (Ph - ALL) that were treated with a modified Dana Farber Cancer Institute (DFCI) chemotherapy regimen containing high dose ASNase as part of the intensification phase.

As noted, before Feb 1, 2008 the intensification phase included ASNase, while after that date ASNase was omitted.

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For the Ph- cases, enoxaparin 0.62 mg/kg was given during intensification from June2009 to Dec2014; following that the dose was increased to 0.90 mg/kg of enoxaparin.

VTE was diagnosed by ultrasound or CT pulmonary embolism study.




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